报告题目：A robust method for designing multistable systems by embedding bistable subsystems

报告人：田天海教授（澳大利亚莫那什大学）

报告时间：2022年4月23日上午10:30-11:30

报告地点：复杂系统研究所（腾讯会议）

报告人简介：田天海， 澳大利亚莫那什大学数学学院教授。2001年在澳大利亚昆士兰大学取得博士学位。在基因网络和细胞信号传导等生物系统的随机建模，随机动力系统的数值模拟，模型参数估计，统计计算和大数据分析等方向开展过很多有创新意义的工作，并取得了较多的研究成果。

报告摘要：In this talk we discuss a robust method to develop multistable mathematical models by embedding bistable models together. Using the GATA1-GATA2-PU.1 module in hematopoiesis as the test system, we discuss a tristable model based on two bistable models without any high cooperative coefficients, and then modify the tristable model based on experimentally determined mechanisms. The modified model successfully realises four stable steady states and accurately reflects a recent experimental observation showing four transcriptional states. The proposed method is a general approach to develop mathematical models for realising multistability and heterogeneity in complex systems.