时间：2021-03-04 | 来源：
基本情况
祁宏，教授，应用数学专业博士生导师、应用统计专业硕士生导师。2014年9月毕业于厦门大学理论物理专业，12月进入山西大学复杂系统研究所工作。拥有跨学科背景，涵盖生物学、物理学、数学和计算机科学等多个领域，擅长数据可视化，对数学魔术有深入研究。主持科技项目6项(其中国家级项目3项)，参与重点项目1项。发表文章44篇 (其中SCI论文30篇)，被引用800余次；参与出版著作一部。
教授课程
大数据分析计算机基础、生物系统的时空分析 (授课对象：研究生)
科研作图与数据可视化 (授课对象：本科生，山西大学通识教育精品课程)
B站链接
https://space.bilibili.com/478308849
研究方向
计算系统生物学、机器学习、数据可视化
学术任职
中国工业与应用数学学会 数学生命科学专业委员会 委员
项目基金
国家自然科学基金面上项目：线粒体膜完整性调控细胞命运的动力学机制研究；项目编号：12275164；执行期限：2023.01-2026.12；金额：55万。
国家自然科学基金数学天元基金项目：前馈环与反馈环耦合网络多稳态行为研究；项目编号：12226317；执行期限：2023.01-2023.12；金额：10万。(访问学者项目，访学单位：北京大学)
国家自然科学基金青年科学基金项目：胞质钙信号调控细胞凋亡的动力学机制研究；项目编号：11504214；执行期限：2016.01-2018.12；金额：22.28万。
山西省高等学校科技创新项目：线粒体通透性转换孔开放导致细胞死亡的机制；项目编号：2019L0015；执行期限：2019.07-2021.07；金额：3万。
山西省青年科技研究基金面上青年基金项目：Bcl-2蛋白通过钙信号调控细胞凋亡的数学建模与分析；项目编号：201901D211159；执行期限：2019.09-2022.09；金额：3万。
温州市生物物理重点实验室开放基金：Bcl-2蛋白家族在炎症和癌症发生中作用的理论研究；项目编号：WIUCASSWWL22003；执行期限：2022.05-2024.05；金额：5万。
研究生
2024级博士： 尹钰淞
2024级硕士： 崔鹏飞、赵瑞、张子珺、陶瑞敏、王文静、赵显晶
2023级硕士： 吕锋、南心雨、高志学、董文晓、赵若兰
2022级硕士： 曹旭清、尹钰淞、马中琳
2021级硕士： 王洋、安致远
2020级硕士： 孙长君
2019级硕士： 史志强、李智超、李爱莎
2017级硕士： 庞兴慧、许国平
2015级硕士： 牛帅
出版书籍
雷锦志, 易鸣, 杨凌, 刘锐, 祁宏. 《系统生物学》, 科学出版社, 2024.
部分论文目录 (Publications, Corresponding author*, Co-first authour#)
Researcher ID in Web of Science http://www.researcherid.com/rid/D-2944-2014
ORCID iD https://orcid.org/0000-0003-2230-1763
1. 祁 宏，苗永旺. 牛αS1酪蛋白基因变异及其与生产性状的关系[J]. 中国牛业科学，2009, 35(4): 39-42. <Cited by 8>Last modified: Nov. 12th, 2024
2. 祁 宏，苗永旺. 牛κ-酪蛋白基因变异及其与奶用性状的关系[J]. 中国牛业科学，2010, 36(4): 51-55.
3. 祁 宏，李卫真，袁峰，李大林，刘丽仙，钱坤，苗永旺. 水牛β-LG基因3,4外显子遗传特性分析[J]. 云南农业大学学报，2011, 26(1): 34-40. {中文核心期刊} <Cited by 1>
4. 祁 宏，刘丽仙，袁峰，李大林，袁跃云，苗永旺. 水牛κ-酪蛋白基因(CSN3)外显子4序列多态性研究[J]. 家畜生态学报，2012，33(2): 13-19. {中文核心期刊} <Cited by 4>
5. 祁 宏，帅建伟*. IP3R钙离子通道集团中的blip动力学[J]. 中国科技论文，2013, 8(6): 534-537. {中文核心期刊} <Cited by 2>
6. Hong Qi, Yandong Huang, Sten Rüdiger, and Jianwei Shuai*. Frequency and relative prevalence of calcium blips and puffs in a model of small IP3R clusters [J]. Biophysical Journal, 2014, 106(11): 2353-2363. (Link) {IF=3.972，SCI二区Top} <Cited by 20>
7. Hong Qi, Linxi Li, and Jianwei Shuai*. Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations [J]. Scientific Reports, 2015, 5: 7984. (Link) {IF=5.578，SCI二区} <Cited by 85>
8. Hong Qi*, Jianwei Shuai*. Alzheimer's disease via enhanced calcium signaling caused by the decrease of endoplasmic reticulum–mitochondrial distance [J]. Medical Hypotheses, 2016, 89: 28–31. (Link)【中文简介】{IF=4.7，SCI四区} <Cited by 26>
9. 陈 圆，祁 宏，李 翔，帅建伟*. 钙离子通道和钙信号震荡模型研究[J]. 生物物理学，2016, 4(1): 1-26. (Link)
10. Xiang Li, Yuan Chen, Hong Qi, Liyu Liu, Jianwei Shuai*. Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling [J]. Oncotarget, 2016, 7(23): 34599-34616. (Link) {IF=5.008，SCI一区} <Cited by 12>
11. Yuan Chen, Hong Qi, Xiang Li, Meichun Cai, Xingqiang Chen, Wen Liu, and Jianwei Shuai*. Suppressing effect of Ca2+ blips on puff amplitudes by inhibiting channels to prevent recovery [J]. Physical Review E, 2016, 94: 022411. (Link) {IF=2.252，SCI三区} <Cited by 6>
12. Xiuhong Cai, Xiang Li, Hong Qi, Fang Wei, Jianyong Chen and Jianwei Shuai*. Comparison of gating dynamics of different IP3R channels with immune algorithm searching for channel parameter distributions [J]. Physical Biology, 2016, 13(5): 056005. (Link) {IF=2.96，SCI三区} <Cited by 6>
13. 尹智勇，杨俊元，祁 宏*. Bcl-2蛋白质家族调控细胞凋亡机制的研究进展[J]. 信阳师范学院学报(自然科学版)，2017, 30(2): 340-344. (Link) {中文核心期刊} <Cited by116> 【学报引用排行榜第一】
14. Zhiyong Yin, Hong Qi#, Lili Liu, Zhen Jin*. The optimal regulation mode of Bcl-2 apoptotic switch revealed by bistability analysis [J]. BioSystems, 2017, 162: 44-52. (Link) {IF=1.96，SCI四区} <Cited by 21>
15. Xiang Li, Jingjing Zhong, Xuejuan Gao, Yuning Wu, Jianwei Shuai, Hong Qi*. Biexponential distribution of open times of a toy channel model [J]. Chinese Physics B, 2017, 26(12): 128703. (Link) {IF=1.436，SCI三区} <Cited by 2>
16. 牛帅，帅建伟*, 祁 宏*. Bcl-2蛋白抑制钙信号的建模与全局动力学分析[J]. 物理学报，2017, 66(23): 238701. (Link) {Acta Physica Sinica, IF=0.624，SCI四区；《物理学报》当期推荐文章} <Cited by 10>
17.Hong Qi, Yu Jiang, Zhiyong Yin, Ke Jiang, Linxi Li, Jianwei Shuai*. Optimal pathways for the assembly of the Apaf-1·cytochrome c complex into apoptosome [J]. Physical Chemistry Chemical Physics, 2018, 20: 1964-1973. (Link) 【中文简介】 {IF=4.449，SCI二区Top} <Cited by 33>
18. 牛帅，孙小强, 祁 宏*. 改进双钙库模型的分岔分析[J]. 中山大学学报(自然科学版)，2018，57(5): 132-139. (Link) {二级学科主学报} <Cited by 5>
19. 许国平，杨鹏, 祁 宏*. Bcl-2蛋白家族调节凋亡和自噬信号通路的研究进展[J]. 中国细胞生物学学报，2019，41(6): 1127-1134. (Link) {一级学科主学报} <Cited by 74>
20. 庞兴慧, 祁 宏*. 基于钙响应钟型曲线构建的钙振荡模型[J]. 厦门大学学报(自然科学版)，2019，58(4): 574-581. (Link) {中文核心期刊} <Cited by 1>
21. 庞兴慧, 祁 宏*. 改进的De Young-Keizer钙振荡模型[J]. 江西师范大学学报(自然科学版)，2019，6: 613-619. (Link) {中文核心期刊} <Cited by 1>
22. Xiang Li, Chuan-Qi Zhong, Zhiyong Yin, Hong Qi, Fei Xu, Qingzu He, Jianwei Shuai*. Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling [J]. International Journal of Molecular Sciences, 2020, 21(9): 3061. (Link) {IF=6.21，SCI二区Top} <Cited by 29>
23. Tomás Gutiérrez, Hong Qi, Megan C. Yap, Nasser Tahbaz, Leanne A. Milburn, Eliana Lucchinetti, Phing-How Lou, Michael Zaugg, Paul G. LaPointe, Pascal Mercier, Michael Overduin, Helmut Bischof, Sandra Burgstaller, Roland Malli, Klaus Ballanyi, Jianwei Shuai, Thomas Simmen*. The ER chaperone calnexin controls mitochondrial positioning and respiration [J]. Science Signaling, 2020, 13(638): eaax6660. (Link) {IF=9.52，Science 子刊；封面文章，实验和理论结合研究} <Cited by 48>
24. Xiang Li, Hong Qi, Xiao-Cui Zhang, Fei Xu, Zhi-yong Yin,Shi-Yang Huang, Zhao-Shou Wang, Jianwei Shuai*. Quantitative modeling of bacterial quorum sensing dynamics in time and space [J]. Chinese Physics B, 2020, 29(10): 108702. (Link) {IF=1.65，SCI三区} <Cited by 3>
25. Hong Qi*, Xiang Li, Zhen Jin, Thomas Simmen, Jianwei Shuai*. The oscillation amplitude, not the frequency of cytosolic calcium, regulates apoptosis induction [J]. iScience, 2020, 23(11): 101671. (Link) 【中文简介】{IF=6.12, SCI二区, Cell 出版社 Research Journal} <Cited by 23>
26. Hong Qi*, Guoping Xu, Xiao-Long Peng, Xiang Li, Jianwei Shuai, Rui Xu*. Roles of four feedback loops in mitochondrial permeability transition pore opening induced by Ca2+ and reactive oxygen species [J]. Physical Review E, 2020, 102(6): 062422. (Link) 【中文简介】 {IF=2.71，SCI三区} <Cited by 12>
27. Xiang Li, Chuan-Qi Zhong, Rui Wu, Xiaozheng Xu, Zhang-Hua Yang, Shaowei Cai, Xiurong Wu, Xin Chen, Zhiyong Yin, Qingzu He, Dianjie Li, Fei Xu, Yihua Yan, Hong Qi, Changchuan Xie, Jianwei Shuai*, Jiahuai Han*. RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes [J]. Protein & Cell, 2021, 12(11): 858-876. (Link) {IF=21.1，SCI一区} <Cited by 97>
28. 李翔, 祁 宏, 黄艳东，帅建伟*. 钙离子信号及细胞调控信号网络动力学[J]. 中国科学:物理学 力学 天文学, 2021, 51(03): 030010. (Link) {一级学科主学报} <Cited by 11>
29. Wen Liu, Xiang Li, Hong Qi, Yuning Wu, Jing Qu, Zhiyong Yin, Xuejuan Gao, Aidong Han, Jianwei Shuai*. Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system [J]. Bioinformatics, 2021, 37(17): 2682–2690. (Link) {IF=6.937，SCI二区Top} <Cited by 12>
30. Xiang Li, Jun Jin, Xiaocui Zhang, Fei Xu, Jinjin Zhong,Zhiyong Yin, Hong Qi, Zhaoshou Wang*, Jianwei Shuai*. Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli [J]. npj Systems Biology and Applications, 2021, 7(1): 35. (Link) {IF=4.67，SCI二区} <Cited by 18>
31. Zhiyong Yin, Pei-pei Zhang#, Fei Xu, Zhilong Liu,Ligang Zhu, Jun Jin, Hong Qi, Jianwei Shuai*, Xiang Li*. Cell death modes are specified by the crosstalk dynamics within pyroptotic and apoptotic signaling [J]. Chaos, 2021, 31(9): 093103. (Link) {IF=3.74，SCI二区，T2期刊} <Cited by 1>
32. Hong Qi(祁宏)*, Zhi-Qiang Shi(史志强), Zhi-Chao Li(李智超), Chang-Jun Sun(孙长君), Shi-Miao Wang(王世苗), Xiang Li(李翔), Jian-Wei Shuai(帅建伟)*. Dual mechanisms of Bcl-2 regulation in IP3-receptor-mediated Ca2+ release: A computational study [J]. Chinese Physics B, 2021, 30(10): 108704. (Link) {IF=1.65，SCI三区；本期亮点文章} <Cited by 3>
33. Hong Qi*, Zhi-Chao Li, Shi-Miao Wang, Lin Wu, Fei Xu, Zhi-Long Liu, Xiang Li*, Jia-Zeng Wang*. Tristability in mitochondrial permeability transition pore opening [J]. Chaos, 2021, 31(12): 123108. (Link) {IF=3.74，SCI二区，T2期刊} <Cited by 10>
34. Xiao-Long Peng, Chun-Yan Li, Hong Qi, Gui-Quan Sun, Zhen Wang*, Yong-Ping Wu*. Competition between awareness and epidemic spreading in homogeneous networks with demography [J]. Applied Mathematics and Computation, 2022, 420: 126875. (Link) {IF=4.397，SCI一区} <Cited by 5>
35. Ligang Zhu, Xiang Li*, Fei Xu, Zhiyong Yin, Jun Jin, Zhilong Liu, Hong Qi, Jianwei Shuai*. Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis [J]. Chaos, Solitons & Fractals, 2022, 155: 111724. (Link){IF=9.92，SCI一区} <Cited by 10>
36. 祁 宏*, 李智超, 史志强. 线粒体膜完整性对细胞命运的调控[J]. 生物化学与生物物理进展，2022，49 (9): 1638-1647. (Link) {Progress in Biochemistry and Biophysics, IF=0.351, SCI三区} <Cited by 7>
37. Li Gao*, Wu-yan Yang, Hong Qi, Chang-Jun Sun, Xue-mei Qin, Guan-hua Du*. Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network [J]. Phytomedicine, 2022, 99: 153990. (Link) {IF=6.66，SCI二区top} <Cited by 6>
38. Xiang Li*, Pei-pei Zhang, Zhiyong Yin, Fei Xu, Zhanghua Yang, Jun Jin, Jing Qu, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai*. Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death [J]. Research, 2022. (Link) {IF=11.04, Science Partner Journal} <Cited by 75>
39. Hong Qi*, Yu-Song Yin, Zhi-yong Yin, Xiang Li, Jian-wei Shuai. Mitochondrial outer membrane permeabilization and inner membrane permeabilization in regulating apoptosis and inflammation [J]. Journal of Theoretical Biology, 2023, 571: 111558. (Link) {IF=2.0，SCI三区，T2期刊} <Cited by 3>
40. Bojie Yang, Zhuoqin Yang*, Heng Liu, Hong Qi*. Dynamic modelling and tristability analysis of misfolded α-synuclein degraded via autophagy in Parkinson's disease [J]. Biosystems, 2023, 233: 105036. (Link) {IF=1.6，SCI四区，T2期刊} <Cited by 3>
41. Jun Jin, Fei Xu#, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai, and Xiang Li*. Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest [J]. Physical Review E, 2023, 108: 064412. (Link) {IF=2.71，SCI三区} <Cited by 17>
42. 祁 宏*, 王洋, 石艳香. 细胞凋亡、坏死和焦亡信号网络关键节点的识别[J]. 河南师范大学学报(自然科学版), 2024, 52(1): 51-59. (Link) <Cited by 2>
43. 祁 宏*, 马中琳, 曹旭清. 前馈环与反馈环的动力学行为研究进展[J]. 山西大学学报(自然科学版)，2024, 47(04): 717-726. (Link)
44. Fei Xu, Xiang Li*, Rui Wu, Hong Qi, Jun Jin, Zhilong Liu, Yuning Wu, Hai Lin, Chuansheng Shen, Jianwei Shuai*. Incoherent feedforward loop dominates the robustness and tunability of necroptosis biphasic, emergent, and coexistent dynamics [J]. Fundamental Research, 2024. (Link) {IF=6.2} <Cited by 1>